One woman has previously been elected to the chamber as an independent, but never served under that designation.
Prognosticators are split as to the vulnerability of this GOP-held seat, but there is no denying a win by the state senator would be a political earthquake in deep red South Dakota.
The number of states with U.S. Senators from different parties might fall to single digits for the first time since the 84th Congress.
The party winning the U.S. House has won a majority of seats in the Minnesota House for 17 of the last 22 cycles including nine of the last 10.